product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
FAK (Tyr-397), phospho-specific, Mouse Monoclonal IgG1
catalog :
MBS470013
quantity :
0.1 mL
price :
380 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
application :
western blot, ELISA
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS470013
products type :
Antibody
products full name :
FAK (Tyr-397), phospho-specific, Mouse Monoclonal IgG1
products short name :
FAK (Tyr-397)
products name syn :
Focal Adhesion Kinase 1; pp125FAK
clonality :
Monoclonal
isotype :
IgG1
host :
Mouse
reactivity :
Human, Rat, Mouse, Rabbit
specificity :
The antibody detects a 125 kDa* protein on SDS-PAGE immunoblots of untreated HUVEC cells. This phosphorylated band is greatly reduced after treatment with alkaline phosphatase.
purity :
Protein A Purified
form :
Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ml phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
storage stability :
Store at –20 degree C. Stable for 1 year.
tested application :
ELISA, Western Blot
app notes :
ELISA: 1:2000. Western Blot: 1:500
other info1 :
Immunogen: Clone (M121) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 397 of human FAK. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse FAK.
other info2 :
Buffer: Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
products description :
Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in signal transduction pathways important for cell spreading, migration and survival. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr-397, which is a binding site for Src family kinases, PI3-Kinase, and PLC-gamma. The recruitment of Src family kinases results in the phosphorylation of tyrosine 407, 576, and 577 in the catalytic domain, and tyrosine 871 and 925 in the carboxy-terminal region of FAK. Thus, the phosphorylation of Tyr-397 is a critical step in the activation of FAK.
products references :
Cobb, B.S. et al. (1994) Mol. Cell. Biol. 14:147. Parsons, J.T. et al. (2000) Oncogene 19:5606. Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14:1680. Schlaepfer, D.D. et al. (1994) Nature 372:786-791.
size1 :
0.1 mL
price1 :
380 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!