product summary
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company name :
MyBioSource
product type :
antibody
product name :
beta-Dystroglycan (Tyr-892), phospho-specific
catalog :
MBS470003
quantity :
0.1 mL
price :
380 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse
application :
western blot, ELISA
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS470003
products type :
Antibody
products full name :
beta-Dystroglycan (Tyr-892), phospho-specific
products short name :
b-Dystroglycan (Tyr-892)
products name syn :
b-Dystroglycan (Tyr-892); phospho-specific; Dystrophin-associated glycoprotein 1; beta-DG; DAG1
clonality :
Monoclonal
isotype :
IgG1
host :
Mouse
reactivity :
Human, Rat, Mouse
specificity :
The antibody detects a 43 kDa* protein on SDS-PAGE immunoblots of human HepG2 or HeLa cells treated with pervanadate, but not in control cells.
purity :
Protein A Purified
form :
Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ml phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
storage stability :
Store at -20 degree C. Do not aliquot. Stable for 1 year.
tested application :
ELISA, Western Blot
app notes :
ELISA: 1:2000. Western Blot: 1:1000
other info1 :
Immunogen: Clone (M117) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 892 of human dystroglycan. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse dystroglycan.
products description :
Dystroglycans are essential elements of the neuromuscular junction (NMJ). The gene for dystroglycan is expressed as a precursor protein that is post-translationally cleaved into a 156 kDa extracellular peripheral membrane protein called a-dystroglycan and a 43 kDa transmembrane protein, b-dystroglycan. The latter protein contains a PPxY motif that promotes binding to WW domain-containing proteins, such as utrophin and dystrophin. Phosphorylation at tyrosine 892 within the PPxY motif may regulate c-Src interactions with beta-dystroglycan, as well as inhibit interactions with WW domain proteins. In skeletal muscle, beta-dystroglycan is normally localized to the plasma membrane, however phosphorylation of Tyr-892 leads to localization of beta-dystroglycan to endosomal compartments along with c-Src. Thus, phosphorylation at Tyr-892 may have important roles in altering the localization of beta-dystroglycan during NMJ formation.
products references :
James, M. et al. (2000) J Cell Sci. 113(Pt 10):1717-1726. Sotgia, F. et al. (2003) Biochem. 42(23):7110-7123.
size1 :
0.1 mL
price1 :
380 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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