anti-human Inducible co-stimulator ligand (ICOSL) monoclonal antibody | MyBioSource MBS468040 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

anti-human Inducible co-stimulator ligand (ICOSL) monoclonal antibody

catalog :

MBS468040

quantity :

0.1 mg

price :

500 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GM-13C1

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS468040

products type :

Antibody

products full name :

anti-human Inducible co-stimulator ligand (ICOSL) monoclonal antibody

products short name :

ICOSL

products name syn :

ICOS ligand

other names :

ICOS ligand isoform b; ICOS ligand; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; inducible T-cell co-stimulator ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275

other gene names :

ICOSLG; ICOSLG; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L; B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1

uniprot entry name :

ICOSL_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

GM-13C1

host :

Mouse

reactivity :

Human

sequence length :

309

specificity :

anti-human Inducible co-stimulator ligand (ICOSL)

purity :

Protein G

form :

Purified

storage stability :

Short term: 2 degree C - 8 degree C; long term: -20 degree C (avoid repeated freezing and thawing)

tested application :

Flow Cytometry (FC/FACS)and CELISA

app notes :

Immunofluorescence: genetic immunisation with cDNA encoding human ICOSL (extracellular domain). Flow Cytometry: 1.2 ug/10^6 cells. CELISA: 1:200 - 1:400

other info1 :

Immunogen: genetic immunisation with cDNA encoding human ICOSL (extracellular domain). Selection: based on recognition of the complete native protein expressed on transfected mammalian cells. Immunogen: cDNA

other info2 :

Buffer: phosphate buffered saline, pH 7.2

products description :

Background: Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS)(1). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion (2,3).

products references :

Richter G, Hayden-Ledbetter M, Irgang M, Ledbetter JA, Westermann J, Korner I, Daemen K, Clark EA, Aicher A and Pezzutto A (2001). Tumor Necrosis Factor-? Regulates the Expression of Inducible Costimulator Receptor Ligand on CD34+ Progenitor Cells during Differentiation into Antigen Presenting Cells. J Biol Chem 276: 45686-45693. Richter G and Burdach S (2004). ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activation. Onkologie 27(1): 91-5. Aicher A, Hayden-Ledbetter M, Brady WA, Pezzutto A, Richer G, Magaletti D, Buckwalter S, Ledbetter JA and Clark EA (2000). Characterization of human inducible costimulator ligand expression and function. J Immunol 1;164(9):4689-96

ncbi gi num :

545688560

ncbi acc num :

NP_001269979.1

ncbi gb acc num :

NM_001283050.1

uniprot acc num :

O75144

ncbi mol weight :

20,120 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670)

uniprot summary :

ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: integral to membrane; plasma membrane. Molecular Function: receptor binding. Biological Process: hyperosmotic response; B cell activation; T cell activation; T cell costimulation; defense response; positive regulation of activated T cell proliferation; signal transduction

size1 :

0.1 mg

price1 :

500 USD

more info or order :

MyBioSource product webpage