antibody

Rabbit anti CDC2 (CT)

MBS462213

0.1 mg

250 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat, fruit fly

western blot, ELISA, immunohistochemistry

Antibody

Rabbit anti CDC2 (CT)

CDC2

Rabbit anti--CDC2 (CT); Cell division control protein 2 (CDC2); Cell division protein kinase 2 (CDK2); CDK1; CDK3; MGC11195; CDC28A

cdc2; CG5363 gene product from transcript CG5363-RA; cdc2; CG5363-PA; cdc2-PA; cyclin-dependent kinase 1; CDC2 kinase; cyclin dependent kinase

CDC2

cdc2; 5363; cdc; Cdc2; CDC2; cdc2Dm; CDCDm; cdk1; Cdk1; CDK1; CDK1/CDC2; CG5363; Dcdc2; Dm cdc2; Dmcdc2; DmCdc2; DmCdk1; DmelCG5363; group 4; l(2)31Eh

Rabbit

Human, Mouse, Rat

This antibody recognizes human, rat and mouse CDC2 protein. The other species are not tested.

The Rabbit IgG is purified by Epitope Affinity Purification.

This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer

Size: 100 ug/200 ul

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

ELISA, Western Blot, Immunohistochemistry

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 1:200

Antigen Preparation: A synthetic peptide corresponding to the C-terminus of CDC2 protein from human, rat and mouse origins.

Positive Control: A431 cell lysate. Cellular Location: Nuclear

Cyclins and cyclin-dependent kinases (CDKs) control cell cycle progression by phosphorlating regulatory proteins. These cyclin-related proteins appear to affect cell structure and function independent of the cell cycle. Cyclins and CDKs have a role in the development and maintenance of cell- and tissue-restricted properties of differentiated cells. CDC2 (Cell Division Cycle 2), also known as CDK1 (Cyclin Dependent kinase 1), is a member of the CDK family of serine/threonin kinases. It is a highly conserved serine protein kinase that plays a key role in regulation of the cell cycle. The phosphorylation of CDC2 at Y15 and T14 during the G2 phase of the cell cycle inhibits CDC2 activity, while the dephosphorylation of Y15 and T14 by CDC25 phosphatase during the late G2 restores its activity.

Shirwin M. Pockwinse, et al. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc Natl Acad Sci U S A. 1997 April 1; 94 (7): 3022-3027.

17136606

NP_476797.1

NM_057449.3

38 kDa

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (365877); APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway (365885); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (365884); ARMS-mediated Activation Pathway (365698); Activated TLR4 Signalling Pathway (365443); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (365882); Axon Guidance Pathway (365557); Cell Cycle Checkpoints Pathway (365939); Cell Cycle, Mitotic Pathway (365831); Cell Cycle Pathway (198250)

0.1 mg

250 USD