Mouse anti CXCR3 Monoclonal antibody | MyBioSource MBS462161 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse anti CXCR3 Monoclonal antibody

catalog :

MBS462161

quantity :

0.1 mg

price :

305 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C6

reactivity :

human

application :

ELISA, immunohistochemistry, flow cytometry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS462161

products type :

Antibody

products full name :

Mouse anti CXCR3 Monoclonal antibody

products short name :

CXCR3

products name syn :

Mouse anti-CXCR3; Chemokine CXC Motif receptor 3; CD183; GPR9; IP10R; MIGR

other names :

C-X-C chemokine receptor type 3 isoform 2; C-X-C chemokine receptor type 3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; OTTHUMP00000032170; OTTHUMP00000070257; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor; chemokine (C-X-C motif) receptor 3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor

products gene name :

CXCR3

other gene names :

CXCR3; CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; GPR9

uniprot entry name :

CXCR3_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

1C6

host :

Mouse

reactivity :

Human

specificity :

This antibody recognizes surface expressed CXCR3, and/or PHA or anti-CD3 activated human T cells. The other species are not tested.

purity :

The mouse IgG1 is purified by Protein A-Affinity Chromatography according to Isotyping

form :

This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer

concentration :

Size: 100 ug/200 ul

storage stability :

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

tested application :

ELISA, Flow Cytometry, Immunohistochemistry

app notes :

Western Blot: 0.5-2 ug/ml. ELISA: 0.1-1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 1:500. Flow Cytometry: 2-5 ug/ml

other info1 :

Antigen Preparation: A 37aa-synthetic peptide corresponding to the N-terminus of human CXCR3 conjugated to KLH.

other info2 :

Positive Control: Transfected CXCR3 Cells. Cellular Location: Cell Membrane

products description :

Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently six CXCspecific receptors designated CXCR1 to CXCR6. This antibody recognizes surface expressed CXCR3, as judged by staining of CXCR3 transfected cells, but not untransfected cells. The antibody also stained human T cells and T cell clones that had been activated in vitro with PHA or anti-CD3. However, the anti-CXCR3 antibody did not react with neutrophils. The CXCR3 receptor is also known as the IP-10 receptor and the Mig receptor.

products references :

Qin S, et al. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 101: 746-754, 1998.

ncbi gi num :

218563730

ncbi acc num :

NP_001136269.1

ncbi gb acc num :

NM_001142797.1

uniprot acc num :

P49682

ncbi mol weight :

~41 kDa

ncbi pathways :

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020)

ncbi summary :

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq]

uniprot summary :

Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Ref.2 Ref.8Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis. Ref.2 Ref.8Isoform 3 mediates the activity of CXCL11. Ref.2 Ref.8. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Ref.2. Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Sequence caution: The sequence CAB02143.1 differs from that shown. Reason: Erroneous initiation.

size1 :

0.1 mg

price1 :

305 USD

more info or order :

MyBioSource product webpage