Rabbit anti Troponin I antibody | MyBioSource MBS462149 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Troponin I antibody

catalog :

MBS462149

quantity :

0.1 mg

price :

370 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS462149

products type :

Antibody

products full name :

Rabbit anti Troponin I antibody

products short name :

Troponin T

products name syn :

Rabbit anti-Troponin T

other names :

troponin T; Troponin T, cardiac muscle; troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant); troponin T type 2 (cardiac); Cardiac muscle troponin T

products gene name :

Troponin T

other gene names :

TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; MGC3889

uniprot entry name :

TNNT2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

specificity :

This antibody recognizes 31 kDa of Troponin T derived from heart tissue lysate by Western blot. It reacts with human canis, felis or rabbit. The other species are not tested.

purity :

The Rabbit IgG is purified by Epitope Affinity Purification

form :

This affinity purified antibody is supplied in sterile Phosphate-buffered saline (pH7.2) containing antibody stabilizer.

concentration :

Size: 100 ug/200 ul

storage stability :

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

tested application :

ELISA, Western Blot, Immunohistochemistry

app notes :

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml

other info1 :

Antigen Preparation: A synthetic peptide corresponding to inter-segment of human Troponin T Cardiac isoform protein.

other info2 :

Positive Control: Cardiac Muscle. Cellular Location: T bands of Myofibrils

ncbi gi num :

547047

ncbi acc num :

AAB30957.1

ncbi gb acc num :

S71127.1

uniprot acc num :

P45379

ncbi mol weight :

31 kDa

ncbi pathways :

Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (106262); Striated Muscle Contraction Pathway (198903)

ncbi summary :

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq]

uniprot summary :

Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Tissue specificity: Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Involvement in disease: Defects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2) [. MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Ref.6 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.24 Ref.26 Ref.28 Ref.30Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [. MIM:601494]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.22 Ref.23 Ref.27 Ref.29Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3) [. MIM:612422]. Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. Sequence similarities: Belongs to the troponin T family.

size1 :

0.1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage