Rabbit anti SOCS-2 antibody | MyBioSource MBS462132 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti SOCS-2 antibody

catalog :

MBS462132

quantity :

0.1 mg

price :

250 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow

application :

western blot, ELISA, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS462132

products type :

Antibody

products full name :

Rabbit anti SOCS-2 antibody

products short name :

SOCS2

products name syn :

Rabbit anti-SOCS-2; Suppressor of Cytokine Signaling 2 (SOCS2);

other names :

suppressor of cytokine signaling 2; Suppressor of cytokine signaling 2; suppressor of cytokine signaling 2; CIS-2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; cytokine-inducible SH2 protein 2; suppressor of cytokine signaling-2; suppressor of cytokine signaling 2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2

products gene name :

SOCS2

other gene names :

SOCS2; SOCS2; CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2; CIS2; SSI2; STATI2

uniprot entry name :

SOCS2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat, Chicken, Bovine, Dog

specificity :

This antibody recognizes ~23 kDa of SOCS-2 protein from human and mouse origins. The other species are not tested.

purity :

The Rabbit IgG is purified by Epitope Affinity Purification.

form :

This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer.

concentration :

Size: 100 ug/200 ul

storage stability :

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

tested application :

ELISA, Western Blot, Immunohistochemistry

app notes :

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 0.5-2 ug/ml

other info1 :

Antigen Preparation: A synthetic peptide corresponding to the C-terminus of SOCS-2 protein from human, mouse and rat origins.

other info2 :

Positive Control: Mouse muscle lysate

products description :

Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS 2 is considered to regulate postnatal growth, such as GH/IGF-1 pathway.

products references :

Bhakta R. Dey, et al. Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor J. Biol. Chem., Sep 1998; 273: 24095 - 24101

ncbi gi num :

4507263

ncbi acc num :

NP_003868.1

ncbi gb acc num :

NM_003877.3

uniprot acc num :

O14508

ncbi mol weight :

23 kDa

ncbi pathways :

IL-3 Signaling Pathway (198881); IL2-mediated Signaling Events Pathway (137976); Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Type II Diabetes Mellitus Pathway (83094); Type II Diabetes Mellitus Pathway (506)

ncbi summary :

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq]

uniprot summary :

Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Pathway: Protein modification; protein ubiquitination. Subunit structure: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. Tissue specificity: High expression in heart, placenta, lung, kidney and prostate. Induction: By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF. Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Sequence similarities: Contains 1 SH2 domain.Contains 1 SOCS box domain.

size1 :

0.1 mg

price1 :

250 USD

more info or order :

MyBioSource product webpage