catalog number :
MBS462128
products full name :
Rabbit anti Shaker
products short name :
Shaker
products name syn :
Rabbit anti Shaker Polyclonal antibody; Shaker; Potassium voltage-gated channel protein shaker; CG12348-PE; Potassium channel protein
specificity :
This antibody recognizes ~73 kDa of Shaker protein.
purity :
The rabbit IgG is purified by Epitope Affinity Purification.
form :
This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
concentration :
100 ug/200 ul
storage stability :
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C to 8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
tested application :
ELISA, Western Blot, Immunohistochemistry
app notes :
Suggested Dilution: . Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/m. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 2-5 ug/ml
other info1 :
Antigen Preparation: A synthetic peptide derived from N-terminus of Shaker protein.
other info2 :
Positive Control: Shaker over-expressed HEK293. Cellular Localization: Membrane
products description :
The assemblage of specific ion channels and receptors at synaptic sites is crucial for signaling between pre- and postsynaptic cells. DLG (Drosophila discs-large gene) is co-localized with Shaker K1 channels, which are clustered at glutamatergic synapses. DLG-Shaker interactions are required in vivo for shaker clustering at the neuromuscular junction. The channel protein Shaker which is properly synthesized, glycosylated, folded, assembled and delivered to the plasma membrane is very important for the potassium channel function.
products references :
Francisco J. Tejedor, et al. Essential Role for dlg in Synaptic Clustering of Shaker K+ Channels In Vivo. The Journal of Neuroscience, January 1, 1997, 17(1):152-159.
ncbi mol weight :
~73 kDa