product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti Phospho- GSK-3alpha (pSer 21)
catalog :
MBS462105
quantity :
0.1 mg
price :
280 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS462105
products type :
Antibody
products full name :
Rabbit anti Phospho- GSK-3alpha (pSer 21)
products short name :
GSK3a (pS21)
products name syn :
Rabbit anti-Phospho-GSK3á (pS21); Glycogen synthase kinase 3 alpha (GSK3á)
other names :
glycogen synthase kinase-3 alpha; Glycogen synthase kinase-3 alpha; glycogen synthase kinase-3 alpha; GSK-3 alpha; OTTHUMP00000198366; OTTHUMP00000198367; OTTHUMP00000198368; glycogen synthase kinase 3 alpha
products gene name :
GSK3a (pS21)
other gene names :
GSK3A; GSK3A; DKFZp686D0638
uniprot entry name :
GSK3A_HUMAN
host :
Rabbit
reactivity :
Human, Mouse, Rat
specificity :
This antibody recognizes GSK-3 alpha (pS21) with a phosphorylated site at Serine 9. It does not cross-react with non-phosphospecific peptide.
purity :
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
form :
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
concentration :
Size: 100 ug/200 ul
storage stability :
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
tested application :
ELISA, Western Blot, Immunohistochemistry
app notes :
Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml
other info1 :
Antigen Preparation: A synthetic peptide surrounding to the epitope -RTSSFA- with a phosphorylation site at Ser21 of human GSK3-alpha protein. This sequence is identical among human, mouse and rat.
other info2 :
Positive Control: 3T3 cell lysate. Cellular Location: Cytoplasmic
products description :
Glycogen Synthase Kinase-3 has two isoforms, GSK-3alpha and GSK3beta. GSK3 is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase as well as the regulation in Wnt signal pathway. GSK-3 alpha reduces the substrates beta-catenin and tau to imply an important role in Wnt signaling and tauopathies such as Alzheimer's disease.
products references :
Ayodeji A Ssuni, et al. GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt (2006). Eur J Neurosci. 24 (12): 3387-92. Yuko Kawakami, et al. Protein Kinase C _II Regulates Akt Phosphorylation on Ser-473 in a Cell Type- and Stimulus-specific Fashion (2004) THE J. Biol. Chem. 279 (46): 47720-47725.
ncbi gi num :
49574532
ncbi acc num :
NP_063937.2
ncbi gb acc num :
NM_019884.2
uniprot acc num :
P49840
ncbi mol weight :
52 kDa
ncbi pathways :
AKT Phosphorylates Targets In The Cytosol Pathway 106475!!Activation Of Chaperones By IRE1alpha Pathway 105906!!B Cell Receptor Signaling Pathway 198909!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class I PI3K Signaling Events Mediated By Akt Pathway 138020!!Diabetes Pathways 105902!!Downstream Signaling Of Activated FGFR Pathway 160957!!FOXM1 Transcription Factor Network Pathway 137935!!Glycogen Metabolism Pathway 198856
ncbi summary :
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
uniprot summary :
Function: Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate. Subunit structure: Monomer. Interacts with ARRB2. Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain.
size :
0.1 mg
price :
280 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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