product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti Phospho-p70S6K (pSer434)
catalog :
MBS462100
quantity :
0.1 mg
price :
265 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, dog, chicken, cow
application :
western blot, ELISA, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS462100
products type :
Antibody
products full name :
Rabbit anti Phospho-p70S6K (pSer434)
products short name :
S6K (pS434)
products name syn :
Rabbit anti-p70S6K (pS434); RPS6KB1; S6K kinase; Ribosomal protein S6K kinase; p70S6K
products gene name :
S6K (pS434)
host :
Rabbit
reactivity :
Human, Rat, Mouse, Chicken, Bovine. Canine
specificity :
This antibody recognizes ~70 kDa of human p70S6K protein. It does not recognize non-phosphorylated peptides. This antibody also reacts with mouse and rat. The other species are not tested
purity :
The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
form :
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
concentration :
Size: 100 ug/200 ul
storage stability :
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. Upon initial thawing, apportion into working aliquots and store at -70 degree C for up to six months. The antibodies can be stored at 2 degree C-8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
tested application :
ELISA, Western Blot, Immunohistochemistry
app notes :
Positive Control: Conditioned 3T3 cells. Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml
other info1 :
Antigen Preparation: A synthetic peptide corresponding to the epitope -IRSPR- at a phosphorylation site at serine 434 of human p70S6K protein. This sequence is identical within human, rat, mouse, bovine, chicken and dog
other info2 :
Positive Control: Conditioned 3T3 cells
products description :
S6 kinase, or p70 S6 Kinase, a mitogen activated Ser/Thr protein kinase, is required for cell growth and G1 cell cycle progression. P70 S6 Kinase and single 4E-BP are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathway which is independent of PI3K and AKT activity. On the other hand, the oncogenic transformation by P3k and Akt is dependent on targets that control translation: transforming activity, which is correlated with phosphorylation and activation of S6K and eliminated by the mTOR inhibitor rapamycin. S6K phosphorylates the S6 protein of the 40S ribosomal subunit.
products references :
Mathieu Miron, et al. Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster. (2003) Molecular and Cellular Biology, 23 (24), 9117-9126.
ncbi mol weight :
70 kDa
size1 :
0.1 mg
price1 :
265 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!