Rabbit anti Connexin 43 antibody | MyBioSource MBS462036 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Connexin 43 antibody

catalog :

MBS462036

quantity :

0.1 mg

price :

340 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

product information

catalog number :

MBS462036

products type :

Antibody

products full name :

Rabbit anti Connexin 43 antibody

products short name :

Connexin 43

products name syn :

Rabbit anti-Connexin43

other names :

gap junction alpha-1 protein; Gap junction alpha-1 protein; gap junction alpha-1 protein; connexin 43; connexin-43; OTTHUMP00000017111; gap junction 43 kDa heart protein; gap junction protein, alpha 1, 43kDa; Connexin-43; Cx43; Gap junction 43 kDa heart protein

products gene name :

Connexin 43

other gene names :

GJA1; GJA1; HSS; CX43; GJAL; ODDD; DFNB38; GJAL

uniprot entry name :

CXA1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

specificity :

This antibody recognizes 43 kDa of Connexin 43 derived from heart tissue or A549 cell lysate by Western blot. It reacts with human, rat and mouse. The other species are not tested.

purity :

The Rabbit IgG is purified by Epitope Affinity Purification

form :

This affinity purified antibody is supplied in sterile Phosphate-buffered saline (pH7.2) containing antibody stabilizer.

concentration :

Size: 100 ug/200 ul

storage stability :

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. Upon initial thawing, apportion into working aliquots and store at -70 degree C for up to six months. The antibodies can be stored at 2 degree C-8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

tested application :

ELISA, Western Blot, Immunohistochemistry

app notes :

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml

other info1 :

Antigen Preparation: A synthetic peptide corresponding to a segment of the 3rd cytoplasmic domain of human/rat connexin 43 protein.

other info2 :

Positive Control: A549 or Heart. Cellular Location: Cytoplasmic

ncbi gi num :

4504001

ncbi acc num :

NP_000156.1

ncbi gb acc num :

NM_000165.3

uniprot acc num :

P17302

ncbi mol weight :

43 kDa

ncbi pathways :

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Calcium Regulation In The Cardiac Cell Pathway 198906!!EGFR1 Signaling Pathway 198782!!Formation Of Annular Gap Junctions Pathway 105934!!Gap Junction Pathway 83072!!Gap Junction Pathway 483!!Gap Junction Assembly Pathway 105928!!Gap Junction Degradation Pathway 105933!!Gap Junction Trafficking Pathway 105927

ncbi summary :

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq]

uniprot summary :

Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Subunit structure: A connexon is composed of a hexamer of connexins. Interacts with SGSM3. Interacts with KIAA1432/CIP150. Interacts with CNST. Ref.16. Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction gap junction. Tissue specificity: Expressed in the heart and fetal cochlea. Ref.15. Involvement in disease: Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [. MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type 3 and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances. Ref.17 Ref.19 Ref.22 Ref.24 Ref.25 Ref.26 Ref.27 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35Defects in GJA1 are the cause of autosomal recessive oculodentodigital dysplasia (ODDD autosomal recessive) [. MIM:257850].Defects in GJA1 may be the cause of syndactyly type 3 (SDTY3) [. MIM:186100]. Syndactyly is an autosomal dominant trait and is the most common congenital anomaly of the hand or foot. It is marked by persistence of the webbing between adjacent digits, so they are more or less completely attached. In this type there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected. Ref.24Defects in GJA1 are a cause of hypoplastic left heart syndrome (HLHS) [. MIM:241550]. HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis. Ref.21Defects in GJA1 are a cause of Hallermann-Streiff syndrome (HSS) [. MIM:234100]. HSS is a disorder characterized by a typical skull shape (brachycephaly with frontal bossing), hypotrichosis, microphthalmia, cataracts, beaked nose, micrognathia, skin atrophy, dental anomalies and proportionate short stature. Mental retardation is present in a minority of cases. Ref.23. Sequence similarities: Belongs to the connexin family. Alpha-type (group II) subfamily. Caution: Ref.20 reported a mutation Pro-364 linked to congenital heart diseases. Ref.12 later shown that it is an artifact.Ref.15 reported 2 mutations (Phe-11 and Ala-24) linked to non-syndromic autosomal recessive deafness (DFNBG). These mutations have subsequently been shown (Ref.19) to involve the pseudogene of connexin-43 located on chromosome 5.

size :

0.1 mg

price :

340 USD