catalog number :
MBS460437
products full name :
Rabbit anti PLAC1 Polyclonal Antibody
products short name :
[PLAC1]
products name syn :
[placenta-specific 1]
other names :
[placenta-specific protein 1; Placenta-specific protein 1; placenta-specific protein 1; placenta specific 1]
products gene name :
[PLAC1]
other gene names :
[PLAC1; PLAC1; CT92; OOSP2L]
reactivity :
Human, Mouse, Rat
specificity :
This antibody recognizes ~22 kDa of PLAC1 protein. It cross-reacts to human, rat and mouse. The other species are not tested.
purity :
Purified by Epitope Affinity Purification
form :
Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
concentration :
0.18 mg/ml
storage stability :
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C to 8 degree C for three months without detectable loss of activity. Avoid repeated freezing-thawing cycles.
tested application :
ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
app notes :
Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunohistochemistry: 0.5-2 ug/ml. Optimal dilutions should be determined by researchers for the specific applications.
image1 heading :
Western Blot (WB)
other info1 :
Preparation: A synthetic peptide corresponding to the C-terminus of mouse PLAC1 protein (from 145aa-175aa). This sequence is identical to human, rat and mouse.
other info2 :
Positive Control: HepG2. Cellular location: Membrane
products description :
The PLAC1, a placenta-specific gene, which encodes a putative cell surface protein, is highly expressed in placenta, testis, cancer cell lines and lung tumors. PLAC1 is exclusively expressed by cells of trophoblastic lineage in the mouse, and maps to a region of the X-chromosome known to be important in placenta growth. PLAC1 is also expressed in human hepatocellular cancer tissues as well as in several other types of cancer tissues and/or tumor cell lines. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination.
products references :
Dong XY, et al. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients. Int J Cancer. 122 (9):2038-43 (2008).
ncbi acc num :
NP_001303817.1
ncbi gb acc num :
NM_001316888.1
ncbi mol weight :
~22 kDa
uniprot summary :
PLAC1: May play a role in placental development. Belongs to the PLAC1 family. Protein type: Cancer Testis Antigen (CTA); Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xq26.3. Biological Process: placenta development