Rabbit anti CCR8 Polyclonal Antibody | MyBioSource MBS460029 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti CCR8 Polyclonal Antibody

catalog :

MBS460029

quantity :

0.1 mg

price :

285 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

The cell lysate derived from Jurkat was immunobloted by the Rabbit anti CCR8 (MBS460029) @1:500. An immunoreactive band is observed at ~40 kDa.

product information

catalog number :

MBS460029

products type :

Antibody

products full name :

Rabbit anti CCR8 Polyclonal Antibody

products short name :

[CCR8]

products name syn :

[C-C chemokine receptor type 8; CC-CKR-8; CCR-8; CDw198; CKRL1]

other names :

[C-C chemokine receptor type 8; C-C chemokine receptor type 8; C-C chemokine receptor type 8; C-C motif chemokine receptor 8; CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1; CD_antigen: CDw198]

products gene name :

[CCR8]

other gene names :

[CCR8; CCR8; CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CKR-L1; GPRCY6]

clonality :

Polyclonal

host :

Rabbit

specificity :

This antibody reacts with human CCR8. The other species are not tested.

purity :

The rabbit polyclonal antibody is purified by Affinity Purification.

form :

This affinity purified antibody is supplied in sterile Phosphate-buffered saline (pH7.2) containing antibody stabilizer

storage stability :

The antibodies are stable for 24 months from date of receipt when stored at –20°C to –70°C. The antibodies can be stored at 2°C-8°C for three months without detectable loss of activity. Avoid repeated freezing-thawing cycles.

tested application :

Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC)

app notes :

WB: 0.1-1 ug/ml. EIA: 0.01-0.1 ug/ml. IP: 2-5 ug/ml. IHC: 2-10 ug/ml. Optimal dilutions should be determined by researchers for the specific applications.

image1 heading :

Western Blot (WB)

other info1 :

Positive Control: Jurkat Cells, Thumus. Cellular Location: Cell Membrane

products description :

CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes.

products references :

Mutalithas, K., Guillen, C., Raport, C., Kolbeck, R., Soler, D., Brightling, C.E., Pavord, I.D. and Wardlaw, A.J. Expression of CCR8 is increased in asthma. Clin. Exp. Allergy 40 (8), 1175-1185 (2010).

ncbi gi num :

4885121

ncbi acc num :

NP_005192.1

ncbi gb acc num :

NM_005201.3

uniprot acc num :

P51685

ncbi mol weight :

40 kDa

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

uniprot summary :

CCR8: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR. Chromosomal Location of Human Ortholog: 3p22.1. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: chemokine receptor activity; coreceptor activity. Biological Process: cell adhesion

size1 :

0.1 mg

price1 :

285 USD

more info or order :

MyBioSource product webpage