CD63 Polyclonal Antibody | MyBioSource MBS448068 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD63 Polyclonal Antibody

catalog :

MBS448068

quantity :

0.6 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

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image 3 :

product information

catalog number :

MBS448068

products type :

Antibody

products full name :

CD63 Polyclonal Antibody

products short name :

[CD63]

products name syn :

[Anti-CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); granulophysin; LAMP-3; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; ME491; melanoma-associated antigen; melanoma 1 antigen; melanoma-associated antigen ME491; MLA1; ocular melanoma-associated antigen; OMA81H; tetraspanin-30; TSPAN30 antibody]

other names :

[CD63 antigen isoform D; CD63 antigen; CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; CD63 molecule; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30]

products gene name :

[CD63]

other gene names :

[CD63; CD63; MLA1; ME491; LAMP-3; OMA81H; TSPAN30; MLA1; TSPAN30; LAMP-3; Tspan-30]

uniprot entry name :

CD63_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Reacts against human, rat, mouse, canine and monkey proteins

sequence length :

156

specificity :

Reacts with CD63, a 40-60 kDa glycoprotein, detected by Western blot in the following human (HeLa, HUH, Jurkat), mouse (AtT-20, Hepa, 3T3, RAW264.7), canine (MDCK) and monkey (COS-7) whole cell lysates.

form :

Polyclonal antibody supplied as a 200 ul(3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.

storage stability :

Store at 2-8°C for one month. Store at -20°C for long term. Avoid freeze/thaw cycles.

tested application :

Immunofluorescence (IF), Western Blot (WB)

app notes :

Western Blot: 1:500-1:5,000. Immunofluorescence: 1:25-1:250

image1 heading :

Reactivity Chart

image2 heading :

Testing Data (TD)

image3 heading :

Immunofluorescence(IF)

other info1 :

Immunogen: Purified recombinant peptide derived from within residues 120 aa to 175 aa of human CD63 produced in E. coli.

other info2 :

Handling: The antibody solution should be gently mixed before use.

products description :

Lysosome-associated membrane glycoprotein 3. CD63 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of the members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker.

ncbi gi num :

383872547

ncbi acc num :

NP_001244330.1

ncbi gb acc num :

NM_001257401.1

uniprot acc num :

P08962

ncbi pathways :

Hemostasis Pathway (106028); Lysosome Pathway (99052); Lysosome Pathway (96865); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

uniprot summary :

Function: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation. Subcellular location: Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note: Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Ref.3 Ref.13 Ref.15 Ref.17 Ref.18. Tissue specificity: Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. Miscellaneous: Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. Sequence similarities: Belongs to the tetraspanin (TM4SF) family.

size1 :

0.6 mg

price1 :

300 USD

size2 :

1.5 mg

price2 :

415

more info or order :

MyBioSource product webpage