catalog number :
MBS440099
products full name :
beta-Tubulin (N14) Antibody
products short name :
beta-Tubulin
other names :
beta-tubulin; Tubulin beta chain; Beta-tubulin
uniprot entry name :
TBB_ACHKL
reactivity :
Mouse, rat, human, rabbit, Xenopus, Drosophila, zebra fish, chicken, dog, pig, cat
specificity :
Recognizes mouse, rat, human, rabbit, Xenopus, Drosophila, zebra fish, chicken, dog, pig, and cat beta-Tubulin.
form :
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
concentration :
0.200 mg/ml
storage stability :
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
tested application :
Western Blot (WB)
app notes :
Recommended Western blotting starting dilution 1:400.
other info1 :
Origin: Beta-Tubulin (N14) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping near the amino terminus of human beta-Tubulin.
other info2 :
Immunogen: A synthetic peptide mapping near the amino terminus of human beta-Tubulin.
products description :
The well-studied members of the Tubulin family of proteins, alpha, beta and gamma have been joined by the newest members delta, epsilon, zeta and eta (1). Microtubule function relies upon alpha-, beta-, and gamma-tubulin. Alpha and beta-Tubulin dimerize to form the microtubule filament, while gamma-tubulin combines with other proteins to form the gammasome that is essential for nucleating microtubule filaments at the centrosome (2). Once formed the microtubules function in chromosome segregation, cell shape maintenance, transport, motility and organelle distribution (3). Drugs (taxol, vinca alkaloids) that can affect the Tubulin-microtubule equilibrium have proven to be effective anticancer drugs.
products references :
1.) Zupanc MM, Wellbrock UM, Zupanc GK. 2006. Proteome analysis identifies novel protein candidates involved in regeneration of the cerebellum of teleost fish. Proteomics Jan;6(2):677-96. 1. Dutcher SK. 2001. The Tubulin fraternity: alpha to eta. Current Opinion Cell Biol. 13(1): 49-54. 2. Leask A, Stearns T. 1998. Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells. J. Biol. Chem. 273(5): 2661-2668. 3. Hadfield JA, Ducki S, Hirst N, McCown AT. 2003. Tubulin and microtubules as targets for anticancer drugs. Prog. Cell Cycle Res. 5:309-325.
ncbi acc num :
AAA63161.1
ncbi mol weight :
49,851 Da