product summary
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company name :
MyBioSource
product type :
antibody
product name :
IkB-alpha (C21) Antibody
catalog :
MBS440066
quantity :
0.2 mg
price :
240 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
more info or order :
product information
catalog number :
MBS440066
products type :
Antibody
products full name :
IkB-alpha (C21) Antibody
products short name :
[IkBalpha]
products gene name :
[IkBalpha]
clonality :
Polyclonal
host :
Rabbit
specificity :
IkB-a (C21) is recommmended to detect mouse, rat and human IkB-a by western blotting, immunoprecipitation, and immunohistochemistry
(including paraffin-embedded tissue).
form :
Each vial contains 200 ug/mL of affinity purified rabbit IgG , IkB-a (C21) DB075, in 1 mL PBS containing 0.1% sodium azide and 0.2% gelatin.
storage stability :
Store this product at 4°C, do not freeze. The product is stable for one year from the date of shipment.
app notes :
Recommended western blotting starting dilution 1:200.
other info1 :
Origin: IkB-alpha (C21) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminal domain of human IkB-alpha. Competition studies: A blocking peptide is also available. DB075P, for use in competition studies. Each vial contains 100 ug of peptide in 0.5 mL PBS with 0.1% sodium azide and 100 ug BSA.
products description :
The NFkB family of transcription factors is sequestered in the cytoplasm by IkB inhibitory proteins (1&2).IkB-alpha and IkB-beta are the two members of this family most often cited for their regulatory function of NFkB directed gene expression. The interaction of NFkB dimers with IkB proteins keeps the complex in the cytoplasm, but upon cellular stimulation the IkB proteins are phosphorylated and subsequently degraded (1&3). The free NFkB can now enter the nucleus and induce gene expression of proteins critical for cellular proliferation, differentation, or apoptosis (1-4).
products references :
1. Schmitz ML, Baeuerle PA. 1995. Multi-step activation of NF-kappa B/Rel transcription factors. Immunobiology 193(2-4):116-127.2. Tran K, Merika M, Thanos D. 1997. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 17(9):5386-5399.3. Tanaka K, Kawakami T, Tateishi K, Yashiroda H, Chiba T. 2001. Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway. Biochimie 83(3-4):351-356.4. Chen CG, Malliaros J, Katerelos M, d?Apice AJ, Pearse MJ. Inhibition of NF-kappaB activation by a dominant-negative mutant of IkappaBalpha. Mol. Immunology 33(1):57-61.
size1 :
0.2 mg
price1 :
240 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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