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company name :
MyBioSource
product type :
antibody
product name :
p130 (C20) Antibody
catalog :
MBS440045
quantity :
0.2 mg
price :
240 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation
more info or order :
product information
catalog number :
MBS440045
products type :
Antibody
products full name :
p130 (C20) Antibody
products short name :
p130
other names :
p130; Retinoblastoma-like protein 2; retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; PRB2; RBR-2; retinoblastoma-related protein 2; retinoblastoma-like 2; 130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2
products gene name :
p130
other gene names :
RBL2; RBL2; Rb2; P130; RB2; p130; RBR-2
uniprot entry name :
RBL2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Mouse, rat, human
sequence length :
1139
specificity :
Mouse, rat and human p130
form :
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
concentration :
0.200 mg/ml
storage stability :
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
tested application :
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
app notes :
Western blotting starting dilution: 1:200.
other info1 :
Origin: p130 (C20) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminal domain of human p130.
other info2 :
Immunogen: Synthetic peptide mapping to the carboxy terminal domain of human p130.
products description :
The pocket protein family consists of three structurally and functionally related proteins, Rb, p107, and p130 (1). This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family (1,2). The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression (3). Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation (4,5). While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F (6). Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb (6,7). Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A (8).
products references :
1. Halaban R. 1999. Melanoma cell autonomous growth: the Rb/E2F pathway. Cancer Metastasis Rev 18(3):333-343.2. Sidle A., Palaty C., Dirks P., Wiggan O., Kiess M., Gill R.M., Wong A.K., Hamel P.A. 1996. Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation. Crit Rev Biochem Mol Biol 31(3):237-271.3. Classon M., Dyson N. 2001. p107 and p130: versatile proteins with interesting pockets. Exp Cell Res 264(1):135-147.4. Hatakeyama M., Weinberg R.A. 1995. The role of RB in cell cycle control. Prog Cell Cycle Res 1:9-19.5. Nevins J.R. 2001. The Rb/E2F pathway and cancer. Hum Mol Genet 10(7):699-703.6. Hurford R.K., Cobrinik D., Lee M.H., Dyson N. 1997. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev 11(11):1447-1463.7. Smith E.J., Leone G., Nevins J.R. 1998. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ 9(4):297-303.8. Knudsen E.S., Wang J.Y. 1998. Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130. Oncogene 16(13):1655-1663.
ncbi gi num :
453132
ncbi acc num :
AAB29227.1
uniprot acc num :
Q08999
ncbi mol weight :
59,349 Da
ncbi pathways :
Adipogenesis Pathway 198832!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Cyclin D Associated Events In G1 Pathway 105767!!DNA Damage Response (only ATM Dependent) Pathway 198827!!E2F Transcription Factor Network Pathway 137934!!FoxO Family Signaling Pathway 138036!!FoxO Signaling Pathway 921162
size :
0.2 mg
price :
240 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
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