Interleukin 10 (IL10) (Immunoregulation Marker) | MyBioSource MBS4380606 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Interleukin 10 (IL10) (Immunoregulation Marker)

catalog :

MBS4380606

quantity :

0.02 mg (With BSA & Azide at 0.2 mg/ml)

price :

190 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

[IL10/2651R]

reactivity :

human

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Formalin-fixed, paraffin-embedded human Endo-cervical Carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).

image 2 :

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).

image 3 :

SDS-PAGE Analysis Purified IL-10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R). Confirmation of Purity and Integrity of Antibody.

product information

catalog number :

MBS4380606

products type :

Antibody

products full name :

Interleukin 10 (IL10) (Immunoregulation Marker)

products short name :

[Interleukin 10 (IL10)]

products name syn :

[Cytokine Synthesis Inhibitory Factor (CSIF); GVHDS; IL-10; IL10; IL10A; Interleukin-10; T-cell Growth Inhibitory Factor (TGIF)]

other names :

[interleukin-10; Interleukin-10; interleukin-10; interleukin 10; Cytokine synthesis inhibitory factor; CSIF]

products gene name :

[IL10]

other gene names :

[IL10; IL10; CSIF; TGIF; GVHDS; IL-10; IL10A; IL-10; CSIF]

clonality :

Monoclonal

isotype :

IgG

clone :

[IL10/2651R]

host :

Rabbit

reactivity :

Human. Others not known.

sequence length :

178

specificity :

Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

form :

200ug/ml of Ab purified by Protein A. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

storage stability :

Antibody with azide store at 2-8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

tested application :

Immunohistology (Formalin-Fixed)

app notes :

Immunohistology (Formalin-Fixed): 1-2ug/ml for 30 minutes at RT ( Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.). Optimal dilution for a specific application should be determined.

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

SDS-Page

other info1 :

Immunogen: Recombinant full-length human Interleukin 10 (IL10) protein. Positive Control: SK-BR3 Cells. Adrenal, Lymph Node, Bladder, Prostate or Endometrium.

other info2 :

Cellular Localization: Cytoplasmic (secreted) and Cell Surface. Chromosome Location: 1q32.1

products description :

Recombinant Rabbit Monoclonal Antibody

products references :

Fleming, S.D. and Campbell, P.A. 1996. Macrophages have cell surface IL-10 that regulates macrophage bactericidal activity. J. Immunol. 156: 1143-1150.; Bromberg, J.S. 1995. IL-10 immunosuppression in transplantation. Curr. Opin. Immunol. 7: 639-643.

ncbi gi num :

10835141

ncbi acc num :

NP_000563.1

ncbi gb acc num :

NM_000572.3

uniprot acc num :

P22301

ncbi mol weight :

20kDa (Monomer); 37kDa (Dimer)

ncbi summary :

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

uniprot summary :

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

size1 :

0.02 mg (With BSA & Azide at 0.2 mg/ml)

price1 :

190 USD

size2 :

0.1 mg (With BSA & Azide at 0.2mg/ml)

price2 :

340

size3 :

0.1 mg (Without BSA & Azide at 1mg/ml)

price3 :

340

more info or order :

MyBioSource product webpage