product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
PIEZO1 Mouse mAb
catalog :
MBS435119
quantity :
0.02 mL
price :
225 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human
application :
immunocytochemistry, immunoprecipitation, flow cytometry, FACS
more info or order :
image
image 1 :
Huvecs transfected with Piezo1-GFP, Staining with mouse anti-human Piezo1 antibody (5 ug/ml, MBS435119).No Permeablized. Recommended dilution:10 ug/ml
image 2 :
Flow cytometric analysis of 2% paraformaldehyde-fixed THP1 (Human acute monocytic leukemia cell line) cells labeling PIEZO1 with MBS435119 at 1/200 dilution (red) compared with a mouse monoclonal IgG isotype control (black) and an unlabelled control (cells without incubation with primary antibody, green). Goat anti-mouse IgG (FITC) at 1/300 dilution was used as the secondary antibody.
product information
catalog number :
MBS435119
products type :
Antibody
products full name :
PIEZO1 Mouse mAb
products short name :
[PIEZO1]
products name syn :
[FAM38A, KIAA0233]
other names :
[piezo-type mechanosensitive ion channel component 1; Piezo-type mechanosensitive ion channel component 1; piezo-type mechanosensitive ion channel component 1; piezo type mechanosensitive ion channel component 1; Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A]
products gene name :
[PIEZO1]
products gene name syn :
[FAM38A; KIAA0233]
other gene names :
[PIEZO1; PIEZO1; DHS; Mib; LMPH3; FAM38A; FAM38A; KIAA0233; Mib]
clonality :
Monoclonal
isotype :
IgG
host :
Mouse
reactivity :
Human
sequence length :
2521
storage stability :
Store at -20 degree C. Stable for one year from the date of shipment.
tested application :
Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
app notes :
Recommended Dilutions: . Immunoprecipitation: 10 tests. Immunofluorescence: 1:100-200. FACS: 1:100-200. For Western Blot (WB), incubate membrane with diluted antibdoy in 5% w/v nonfat dry milk, 1x TBS, 0.05% Tween-20 at 4 degree C with gentle shaking overnight.
image1 heading :
Immunofluorescence (IF)
image2 heading :
Flow Cytometry (FC/FACS)
other info1 :
Source: This monoclonal antibody is produced by immunizing mice with a polypeptide corresponding to PIEZO1 protein.
products categories :
Cell Marker; Subcellular Marker; Membrane
products description :
The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis.
ncbi gi num :
257196142
ncbi acc num :
NP_001136336.2
ncbi gb acc num :
NM_001142864.4
uniprot acc num :
Q92508
ncbi mol weight :
286.6 kDa
ncbi summary :
The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]
uniprot summary :
Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology ().
size1 :
0.02 mL
price1 :
225 USD
size2 :
0.05 mL
price2 :
350
size3 :
0.1 mL
price3 :
565
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
related products
browse more products
questions and comments