catalog number :
MBS434076
products type :
Recombinant Protein
products full name :
rhesus macaque CD4 protein (amino acid 1-398)
products short name :
CD4 protein
products name syn :
rhesus macaque CD4 protein; glycosylated recombinant protein; CD4 (rhesus macaque); rhesus macaque CD4 protein (aa 1-398), glycosylated
other names :
T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 antigen; T-cell surface antigen T4/Leu-3; T-cell surface antigen T4/Leu-3; CD_antigen: CD4
other gene names :
CD4; CD4
uniprot entry name :
CD4_MACMU
purity :
> 95% (SDS-PAGE)
concentration :
1 mg/ml in PBS
storage stability :
Store at -20 degree C. Stable for 6-months from the date of shipment when kept at 4 degree C. Non-hazardous. No MSDS required.
tested application :
Western Blot (WB), ELISA (EIA), Immunogen
app notes :
SDS-PAGE Data: purified rhesus macaque CD4 protein
other info2 :
Viral Protein: C-terminal 6xHis tagged rhesus macaque CD4 protein (amino acid 1-398) (Genebank No. NP_001036127).
products categories :
Viral Recombinant Proteins; HIV/SIV
products description :
Description: 6xHis tagged rhesus macaque CD4 protein (amino acid 1-398) (Genebank No. NP_001036127). Viral protein expressed and purified from 293 cell culture. Introduction: CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. CD4+ T helper cells are white blood cells that are an essential part of the human immune system. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. HIV-1/SIV-1 uses CD4 to gain entry into host T-cells and achieves this through its viral envelope protein known as gp120. The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor expressed on the host cell. These co-receptors are chemokine receptors CCR5 or CXCR4. Following a structural change in another viral protein (gp41), HIV inserts a fusion peptide into the host cell that allows the outer membrane of the virus to fuse with the cell membrane.
ncbi acc num :
NP_001036127.1
ncbi gb acc num :
NM_001042662.1
ncbi mol weight :
50,884 Da