protein

HDAC3 Immunizing Peptide

MBS428684

0.1 mg

190 USD

Blocking Peptide

HDAC3 Immunizing Peptide

[HDAC3]

[HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; SMAP45]

[histone deacetylase 3; Histone deacetylase 3; histone deacetylase 3; histone deacetylase 3; RPD3-2; SMAP45]

[HDAC3]

[HDAC3; HDAC3; HD3; RPD3; RPD3-2; HD3]

HDAC3_HUMAN

Human, Mouse, Rat, Dog, Pig, Cow

428

C-NHAPSVQIHDVPAD

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Uses: The peptide was used in the production of MBS428684-Goat Anti-HDAC3 Antibody. It is currently untested in blocking applications.

13128862

NP_003874.2

NM_003883.3

49,111 Da

Activation Of HOX Genes During Differentiation Pathway (1339139); Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway (1339140); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway (1268699); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (1269872); Cell Cycle Pathway (198811); Chaperonin-mediated Protein Folding Pathway (1268694); Chromatin Modifying Enzymes Pathway (1270434); Chromatin Organization Pathway (1270433)

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

HDAC3: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Widely expressed. Belongs to the histone deacetylase family. HD type 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Cell cycle regulation; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; nucleoplasm; nucleus; plasma membrane; spindle microtubule; transcriptional repressor complex. Molecular Function: chromatin binding; cyclin binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; NF-kappaB binding; protein binding; protein deacetylase activity; transcription corepressor activity; transcription factor binding. Biological Process: cellular lipid metabolic process; circadian rhythm; establishment and/or maintenance of chromatin architecture; negative regulation of apoptosis; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; positive regulation of TOR signaling pathway; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein amino acid deacetylation; regulation of protein stability; spindle assembly

0.1 mg

190 USD