protein

proSAAS Immunizing Peptide

MBS428625

0.1 mg

190 USD

Blocking Peptide

proSAAS Immunizing Peptide

[proSAAS]

[PCSK1N; proprotein convertase subtilisin/kexin type 1 inhibitor; PROSAAS; SAAS; granin-like neuroendocrine peptide; pro-SAAS; proSAAS; proprotein convertase 1 inhibitor]

[proSAAS preproprotein; ProSAAS; proSAAS; proprotein convertase subtilisin/kexin type 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; Proprotein convertase 1 inhibitor]

[PCSK1N]

[proSAAS]

[PCSK1N; PCSK1N; PEN; SAAS; SCG8; BigLEN; SgVIII; PROSAAS; Proprotein convertase 1 inhibitor; b-SAAS; l-SAAS; b-PEN-LEN; l-LEN; b-LEN]

PCSK1_HUMAN

Human, Mouse

260

C-EAGDETPDVDPE

100 ug of Lyophilised peptide, formulation 5pmol/uL in 5% (v/v) acetonitrile/H2O.Reconstitute pellet in distilled water where required. For Blocking studies, reconstitute pellet in 200 ul distilled water to obtain a 0.5 mg/ml peptide solution.

Shipped at ambient temperature, store at -20 degree C

Use: The peptide was used in the production of MBS428625 – Goat Anti-proSAAS Antibody. It iscurrently untested in blocking applications.

7019519

NP_037403.1

NM_013271.4

27,372 Da

The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]

PCSK1N: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xp11.23. Cellular Component: extracellular space; secretory granule; trans-Golgi network. Molecular Function: endopeptidase inhibitor activity; receptor binding; serine-type endopeptidase inhibitor activity. Biological Process: neuropeptide signaling pathway; peptide hormone processing; response to cold; response to dietary excess

0.1 mg

190 USD