protein

PRODH Immunizing Peptide

MBS428619

0.1 mg

190 USD

Blocking Peptide

PRODH Immunizing Peptide

[PRODH]

[PRODH; proline dehydrogenase (oxidase) 1; HSPOX2; PIG6; PRODH1; PRODH2; SCZD4; TP53I6; FLJ33744; MGC148078; MGC148079; Proline oxidase, mitochondrial; p53 induced protein; proline dehydrogenase (proline oxidase); proline oxidase 2; tumor protein p53 ind]

[proline dehydrogenase (oxidase) 1; Proline dehydrogenase 1, mitochondrial; proline dehydrogenase 1, mitochondrial; proline dehydrogenase 1; Proline oxidase; Proline oxidase 2; p53-induced gene 6 protein]

[PRODH]

[PRODH; PRODH; POX; PIG6; HSPOX2; PRODH1; PRODH2; TP53I6; PIG6; POX2]

PROD_HUMAN

Human, Mouse

600

C-ERDGSGTNKRDKQYQ

100ug of Lyophilized peptide, formulation 5pmol/uL in 5% (v/v) acetonitrile/H2O. Reconstitute in pellet in distilled water where required. For blocking studies, reconstitute pellet in 200 uL distilled water to obtain a 0.5 mg/mL peptide solution.

Shipped at ambient temperature, store at -20°C

The peptide was udes in the production MBS428619-Goat Anti-PRODH Antibody. It is currently untested in blocking applications.

19924111

NP_057419.2

NM_016335.2

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway (1309221); L-citrulline Biosynthesis Pathway (138212); L-proline Degradation Pathway (139198); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Proline Catabolism Pathway (1270165); Superpathway Of L-citrulline Metabolism (703106)

This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

PRODH: Converts proline to delta-1-pyrroline-5-carboxylate. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1). HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Belongs to the proline oxidase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - arginine and proline; Mitochondrial; Oxidoreductase; EC 1.5.5.2. Chromosomal Location of Human Ortholog: 22q11.21. Cellular Component: mitochondrial inner membrane; mitochondrial matrix. Molecular Function: proline dehydrogenase activity. Biological Process: 4-hydroxyproline catabolic process; induction of apoptosis by oxidative stress; proline catabolic process; proline catabolic process to glutamate; proline metabolic process. Disease: Hyperprolinemia, Type I; Schizophrenia 4

0.1 mg

190 USD