FMR1 Immunizing Peptide | MyBioSource MBS428020 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

FMR1 Immunizing Peptide

catalog :

MBS428020

quantity :

0.1 mg

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS428020

products type :

Blocking Peptide

products full name :

FMR1 Immunizing Peptide

products short name :

[FMR1]

products name syn :

[FMR1; fragile X mental retardation 1; FMRP; FRAXA; MGC87458]

other names :

[fragile X mental retardation protein 1 isoform ISO1; Fragile X mental retardation protein 1; fragile X mental retardation protein 1; fragile X mental retardation 1]

products gene name :

[FMR1]

other gene names :

[FMR1; FMR1; POF; FMRP; POF1; FRAXA; FMRP; Protein FMR-1]

uniprot entry name :

FMR1_HUMAN

host :

Goat

sequence length :

632

sequence :

C-RTGKDRNQKKEKPD

storage stability :

Shipped at ambient temperature, store at -20 degree C

other info1 :

Use: The peptide was used in the production of MBS428020 -- Goat anti-FMR1 Antibody. It is currently untested in blocking applications. Supplied As: 100ug of Lyophilized peptide, formulation 5pmol/ul in 5% (v/v) acetonitrile/H2O. Reconstitute pellet in distilled water where required. For Blocking studies, reconstitute pellet in 200ul distilled water to obtain a 0.5mg/ml peptide solution.

ncbi gi num :

4503765

ncbi acc num :

NP_002015.1

ncbi gb acc num :

NM_002024.5

ncbi pathways :

RNA Transport Pathway (177876); RNA Transport Pathway (175229)

ncbi summary :

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]

uniprot summary :

FMR1: Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C). Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with CYFIP1 and CYFIP2. The interaction with brain cytoplasmic RNA 1 (BC1) increases binding affinity for the CYFIP1-EIF4E complex in the brain. Homooligomer. Found in a RNP granule complex with IGF2BP1. Directly interacts with SMN and TDRD3. Interacts with the SMN core complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts with FXR1, FXR2, IGF2BP1, NUFIP1, NUFIP2, MCRS1 and RANBP9. Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. Belongs to the FMR1 family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; Translation; Nucleolus. Chromosomal Location of Human Ortholog: Xq27.3. Cellular Component: axon; Cajal body; cell projection; cytoplasm; dendrite; dendritic shaft; dendritic spine; extrinsic to plasma membrane; growth cone; membrane; mRNA cap complex; nerve terminal; neuron projection; nucleolus; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; polysomal ribosome; polysome; postsynaptic density; ribonucleoprotein complex; SMN complex. Molecular Function: dynein binding; identical protein binding; microtubule binding; miRNA binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; poly(rG) binding; poly(U) binding; protein binding; protein heterodimerization activity; protein homodimerization activity; ribosome binding; RNA binding; RNA strand annealing activity; siRNA binding; translation initiation factor binding; translation repressor activity. Biological Process: glutamate signaling pathway; mRNA transport; negative regulation of translation; negative regulation of translational initiation; positive regulation of filopodium formation; positive regulation of translation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of mRNA stability; regulation of neurotransmitter secretion. Disease: Fragile X Mental Retardation Syndrome; Fragile X Tremor/ataxia Syndrome; Premature Ovarian Failure 1

size1 :

0.1 mg

price1 :

190 USD

more info or order :

MyBioSource product webpage