protein

AMACR Immunizing Peptide

MBS428004

0.1 mg

190 USD

Blocking Peptide

AMACR Immunizing Peptide

[AMACR]

[AMACR; alpha-methylacyl-CoA racemase; AMACRD; CBAS4; RACE; RM; 2-methylacyl-CoA racemase; AMACR (aa312-326)]

[alpha-methylacyl-CoA racemase isoform 1; Alpha-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase]

[AMACR]

[AMACR; AMACR; RM; RACE; CBAS4; AMACRD]

AMACR_HUMAN

Human

382

C-RGSFITSEEQDVSPR

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Use: The peptide was used in the production of MBS428004 - Goat Anti-AMACR (aa312-326) Antibody. It is currently untested in blocking applications.

Supplied As: 100ug of Lyophilised peptide, formulation 5pmol/uL in 5% (v/v) acetonitrile/H20. Reconstitute pellet in distilled water where required. For Blocking studies, reconstitute pellet in 200ul distilled water to obtain a 0.5mg/ml peptide solution.

42794625

NP_055139.4

NM_014324.5

43,860 Da

Beta-oxidation Of Pristanoyl-CoA Pathway (1270033); Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway (413432); Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway (468297); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Peroxisomal Lipid Metabolism Pathway (1270031); Peroxisome Pathway (131226); Peroxisome Pathway (131126)

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

AMACR: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 5.1.99.4; Isomerase; Mitochondrial; Lipid Metabolism - primary bile acid biosynthesis. Chromosomal Location of Human Ortholog: 5p13. Cellular Component: cytoplasm; mitochondrion; peroxisomal matrix; peroxisome. Molecular Function: alpha-methylacyl-CoA racemase activity; receptor binding. Biological Process: bile acid biosynthetic process; bile acid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase. Disease: Alpha-methylacyl-coa Racemase Deficiency; Bile Acid Synthesis Defect, Congenital, 4

0.1 mg

190 USD