protein

ABCD2 Immunizing Peptide

MBS427957

0.1 mg

190 USD

Peptide

ABCD2 Immunizing Peptide

ABCD2

ABCD2; ATP-binding cassette, sub-family D (ALD), member 2; ABC39; ALDL1; ALDR; ALDRP; hALDR; ATP-binding cassette sub-family D member 2; adrenoleukodystrophy-like 1; adrenoleukodystrophy-related protein; ABCD2 (aa460-473)

ATP-binding cassette sub-family D member 2; ATP-binding cassette sub-family D member 2; ATP-binding cassette sub-family D member 2; ATP binding cassette subfamily D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR

ABCD2

ABCD2; ABCD2; ALDR; ABC39; ALDL1; ALDRP; hALDR; ALD1; ALDL1; ALDR; ALDRP; hALDR

ABCD2_HUMAN

Human

740

C-PLSDTLAIKGKVID

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

9945308

NP_005155.1

NM_005164.3

83,233 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC Transporters In Lipid Homeostasis Pathway (1269905); ABC-family Proteins Mediated Transport Pathway (1269904); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Peroxisome Pathway (131226); Peroxisome Pathway (131126); Transmembrane Transport Of Small Molecules Pathway (1269903)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]

ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family. Chromosomal Location of Human Ortholog: 12q12. Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome. Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity. Biological Process: fatty acid beta-oxidation; long-chain fatty acid transport; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process

0.1 mg

190 USD