protein

IRF4 Immunizing Peptide

MBS427645

0.1 mg

190 USD

Blocking Peptide

IRF4 Immunizing Peptide

[IRF4]

[IRF4; interferon regulatory factor 4; LSIRF; MUM1; multiple myeloma oncogene 1]

[interferon regulatory factor 4 isoform 1; Interferon regulatory factor 4; interferon regulatory factor 4; interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5]

[IRF4]

[IRF4; IRF4; MUM1; LSIRF; SHEP8; NF-EM5; MUM1; IRF-4; LSIRF]

IRF4_HUMAN

Human

451

C-HISNPEDYHRSIR

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

167555104

NP_002451.2

NM_002460.3

51,644 Da

Apoptosis Pathway (198797); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cytokine Signaling In Immune System Pathway (1269310); IL4-mediated Signaling Events Pathway (137933); Immune System Pathway (1269170); Interferon Signaling Pathway (1269311); Interferon Alpha/beta Signaling Pathway (1269312); Interferon Gamma Signaling Pathway (1269314); TCR Signaling Pathway (198862); Type II Interferon Signaling (IFNG) Pathway (198918)

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oncoprotein; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 6p25-p23. Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus. Molecular Function: protein binding; protein-lysine N-methyltransferase activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding. Biological Process: defense response to protozoan; myeloid dendritic cell differentiation; negative regulation of toll-like receptor signaling pathway; peptidyl-lysine methylation; positive regulation of DNA binding; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of T-helper cell differentiation; T cell activation; transcription from RNA polymerase II promoter. Disease: Skin/hair/eye Pigmentation, Variation In, 8

0.1 mg

190 USD