protein

Muc5b Immunizing Peptide

MBS427566

0.1 mg

190 USD

Peptide

Muc5b Immunizing Peptide

Muc5b

Muc5b; mucin 5, subtype B, tracheobronchial; 2300002I04Rik; A130042M24; AV085033; MUC5; MUC9; mucin 5b; Muc5b (mouse)

mucin-5B; Mucin-5B; mucin-5B; mucin 5B, oligomeric mucus/gel-forming; Cervical mucin; High molecular weight salivary mucin MG1; Mucin-5 subtype B, tracheobronchial; Sublingual gland mucin

Muc5b

MUC5B; MUC5B; MG1; MUC5; MUC9; MUC-5B; MUC5; MUC-5B

MUC5B_HUMAN

Human, Mouse, Rat

5765

QHTYTHIDECN

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

153945878

NP_002449.1

NM_002458.1

596,340 Da

Defective C1GALT1C1 Causes Tn Polyagglutination Syndrome (TNPS) Pathway (1383050); Defective GALNT12 Causes Colorectal Cancer 1 (CRCS1) Pathway (1383052); Defective GALNT3 Causes Familial Hyperphosphatemic Tumoral Calcinosis (HFTC) Pathway (1383051); Disease Pathway (1268854); Diseases Associated With O-glycosylation Of Proteins Pathway (1383049); Diseases Of Glycosylation Pathway (1269010); Metabolism Of Proteins Pathway (1268677); O-linked Glycosylation Pathway (1268734); O-linked Glycosylation Of Mucins Pathway (1268736); Post-translational Protein Modification Pathway (1268701)

This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

MUC5B: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Defects in MUC5B are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741). Protein type: Secreted; Secreted, signal peptide; Cell adhesion. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: extracellular space; Golgi lumen; intracellular membrane-bound organelle. Molecular Function: protein binding. Biological Process: defense response to bacterium; O-glycan processing; regulation of macrophage activation. Disease: Pulmonary Fibrosis, Idiopathic

0.1 mg

190 USD