catalog number :
MBS427520
products full name :
Tph2 Immunizing Peptide
products short name :
Tph2
products name syn :
Tph2; tryptophan hydroxylase 2; AU043594; MGC159133; Ntph; OTTMUSP00000022885; neuronal tryptophan hydroxylase; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2; Tph2 (mouse)
other names :
tryptophan 5-hydroxylase 2; Tryptophan 5-hydroxylase 2; tryptophan 5-hydroxylase 2; tryptophan hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
products gene name :
Tph2
other gene names :
Tph2; Tph2; Ntph; AU043594; Ntph
uniprot entry name :
TPH2_MOUSE
sequence :
C-SLTQNKAIKSEDK
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_775567.2
ncbi gb acc num :
NM_173391.3
ncbi mol weight :
55,859 Da
ncbi pathways :
Amine-derived Hormones Pathway (1367834); Melatonin Biosynthesis, Tryptophan = Serotonin = Melatonin Pathway (421793); Melatonin Biosynthesis, Tryptophan = Serotonin = Melatonin Pathway (468230); Metabolic Pathways (132962); Metabolism Pathway (1367614); Metabolism Of Amino Acids And Derivatives Pathway (1367816); SIDS Susceptibility Pathways (198328); Serotonergic Synapse Pathway (525339); Serotonin And Melatonin Biosynthesis Pathway (1367838); Tryptophan Metabolism Pathway (83163)
uniprot summary :
TPH2: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1. Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase. Cellular Component: neuron projection. Molecular Function: amino acid binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; tryptophan 5-monooxygenase activity. Biological Process: aromatic amino acid family metabolic process; metabolic process; serotonin biosynthetic process; serotonin biosynthetic process from tryptophan