product summary
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company name :
MyBioSource
product type :
protein
product name :
TPH2 Immunizing Peptide
catalog :
MBS427453
quantity :
0.1 mg
price :
190 USD
more info or order :
product information
catalog number :
MBS427453
products type :
Peptide
products full name :
TPH2 Immunizing Peptide
products short name :
TPH2
products name syn :
TPH2; tryptophan hydroxylase 2; ADHD7; FLJ37295; MGC138871; MGC138872; NTPH; neuronal tryptophan hydroxylase; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2; TPH2 (aa16-29)
other names :
tryptophan 5-hydroxylase 2; Tryptophan 5-hydroxylase 2; tryptophan 5-hydroxylase 2; tryptophan hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
products gene name :
TPH2
other gene names :
TPH2; TPH2; NTPH; ADHD7; NTPH
uniprot entry name :
TPH2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence length :
490
sequence :
RGFSLDSAVPEEHQ-C
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi gi num :
31795563
ncbi acc num :
NP_775489.2
ncbi gb acc num :
NM_173353.3
ncbi mol weight :
56,242 Da
ncbi pathways :
Amine-derived Hormones Pathway (1270175); Melatonin Biosynthesis, Tryptophan = Serotonin = Melatonin Pathway (413355); Melatonin Biosynthesis, Tryptophan = Serotonin = Melatonin Pathway (468230); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Monoamine Transport Pathway (198851); SIDS Susceptibility Pathways (198901); Serotonergic Synapse Pathway (525336); Serotonin Transporter Activity Pathway (920962)
ncbi summary :
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
uniprot summary :
TPH2: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1. Protein type: EC 1.14.16.4; Amino Acid Metabolism - tryptophan; Oxidoreductase. Chromosomal Location of Human Ortholog: 12q21.1. Cellular Component: cytosol; neuron projection. Molecular Function: amino acid binding; iron ion binding; tryptophan 5-monooxygenase activity. Biological Process: aromatic amino acid family metabolic process; circadian rhythm; indolalkylamine biosynthetic process; response to activity; response to calcium ion; response to estrogen stimulus; response to glucocorticoid stimulus; response to nutrient levels; serotonin biosynthetic process. Disease: Attention Deficit-hyperactivity Disorder, Susceptibility To, 7; Major Depressive Disorder
size1 :
0.1 mg
price1 :
190 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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