protein

ANGPT1 Immunizing Peptide

MBS427424

0.1 mg

190 USD

Peptide

ANGPT1 Immunizing Peptide

ANGPT1

ANGPT1; angiopoietin 1; AGP1; AGPT; ANG1

angiopoietin-1 isoform 1; Angiopoietin-1; angiopoietin-1; angiopoietin 1

ANGPT1

ANGPT1; ANGPT1; AGP1; AGPT; ANG1; KIAA0003; ANG-1

ANGP1_HUMAN

Human, Mouse, Rat, Dog, Cow, Pig

498

C-PDFSSQKLQH

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

20532340

NP_001137.2

NM_001146.4

57,456 Da

ARMS-mediated Activation Pathway (1269471); Angiogenesis Pathway (198772); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Axon Guidance Pathway (1270303); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Downstream Signal Transduction Pathway (1269479)

This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

ANGPT1: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q23.1. Cellular Component: extracellular region; extracellular space; intracellular; lipid raft; microvillus; plasma membrane. Molecular Function: protein binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding. Biological Process: cell differentiation; cell-substrate adhesion; hemopoiesis; heparin biosynthetic process; in utero embryonic development; leukocyte migration; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of cytokine secretion during immune response; negative regulation of neuron apoptosis; negative regulation of protein amino acid phosphorylation; negative regulation of protein import into nucleus; negative regulation of vascular permeability; positive chemotaxis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of receptor internalization; regulation of endothelial cell proliferation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of protein binding; regulation of satellite cell proliferation; regulation of tumor necrosis factor production; sprouting angiogenesis; Tie receptor signaling pathway; transmembrane receptor protein tyrosine kinase activation (dimerization)

0.1 mg

190 USD