catalog number :
MBS427217
products full name :
Aconitase 2 Immunizing Peptide
products short name :
Aconitase 2
products name syn :
ACO2; aconitase 2, mitochondrial; ACONM; MGC20605; MGC33908; aconitate hydratase; citrate hydro-lyase; Aconitase 2; Aconitase 2 (aa541-555)
other names :
aconitate hydratase, mitochondrial; Aconitate hydratase, mitochondrial; aconitate hydratase, mitochondrial; aconitase 2; Citrate hydro-lyase
products gene name :
ACO2
other gene names :
ACO2; ACO2; ICRD; OCA8; OPA9; ACONM; HEL-S-284; Aconitase
uniprot entry name :
ACON_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow, Pig
sequence :
C-QDTYQHPPKDSSGQH
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_001089.1
ncbi gb acc num :
NM_001098.2
ncbi mol weight :
85,425 Da
ncbi pathways :
2-Oxocarboxylic Acid Metabolism Pathway (714485); 2-Oxocarboxylic Acid Metabolism Pathway (717400); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Citrate Cycle (TCA Cycle) Pathway (82927); Citrate Cycle (TCA Cycle) Pathway (288); Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway (855811); Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway (468202)
ncbi summary :
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
uniprot summary :
ACO2: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family. Protein type: Mitochondrial; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle; Lyase; EC 4.2.1.3. Chromosomal Location of Human Ortholog: 22q13.2. Cellular Component: mitochondrial matrix; mitochondrion; myelin sheath; nucleus. Molecular Function: 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; iron ion binding. Biological Process: citrate metabolic process; generation of precursor metabolites and energy; isocitrate metabolic process; tricarboxylic acid cycle. Disease: Infantile Cerebellar-retinal Degeneration; Optic Atrophy 8