catalog number :
MBS427195
products full name :
Mesothelin Immunizing Peptide
products short name :
Mesothelin
products name syn :
MSLN; mesothelin; CAK1; MPF; SMR; megakaryocyte potentiating factor; Mesothelin; Mesothelin
other names :
mesothelin isoform 1 preproprotein; Mesothelin; mesothelin; mesothelin; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
products gene name :
MSLN
other gene names :
MSLN; MSLN; MPF; SMRP; MPF; MPF
uniprot entry name :
MSLN_HUMAN
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_005814.2
ncbi gb acc num :
NM_005823.5
ncbi mol weight :
67,940 Da
ncbi summary :
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
uniprot summary :
MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor; Cell adhesion. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: cell surface; extracellular space; Golgi apparatus; membrane; plasma membrane. Molecular Function: protein binding. Biological Process: cell adhesion; cell-matrix adhesion; pancreas development