protein

ABCB9 / TAPL Immunizing Peptide

MBS426771

0.1 mg

190 USD

Peptide

ABCB9 / TAPL Immunizing Peptide

ABCB9 / TAPL

ABCB9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; TAPL; KIAA1520; EST122234; ABCB9 / TAPL

ATP-binding cassette sub-family B member 9 isoform 2; ATP-binding cassette sub-family B member 9; ATP-binding cassette sub-family B member 9; ATP binding cassette subfamily B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL

ABCB9

TAPL

ABCB9; ABCB9; TAPL; EST122234; KIAA1520; ABC transporter 9 protein; hABCB9; TAPL

ABCB9_HUMAN

Human

723

C-GHNEPVANGSHKA

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

9955968

NP_062570.1

NM_019624.3

77,470 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (1269904); Lysosome Pathway (99052); Lysosome Pathway (96865); Transmembrane Transport Of Small Molecules Pathway (1269903)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Transporter; Transporter, ABC family; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q24. Cellular Component: early endosome; endoplasmic reticulum; integral to endoplasmic reticulum membrane; integral to membrane; lysosomal membrane; lysosome. Molecular Function: ATP binding; oligopeptide-transporting ATPase activity; peptide-transporting ATPase activity; protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity. Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; metabolic process; peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; protein transport; transmembrane transport

0.1 mg

190 USD