catalog number :
MBS426630
products full name :
Ide Immunizing Peptide
products short name :
Ide
products name syn :
Ide; insulin-degrading enzyme; 1300012G03Rik; 4833415K22Rik; AA675336; AI507533; INSULYSIN; insulinase; insulysin; Ide (mouse)
other names :
insulin-degrading enzyme; Insulin-degrading enzyme; insulin-degrading enzyme; insulin degrading enzyme; Insulin protease; Insulinase; Insulysin
other gene names :
Ide; Ide; AA675336; AI507533; 1300012G03Rik; 4833415K22Rik; Insulinase
uniprot entry name :
IDE_MOUSE
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_112419.2
ncbi gb acc num :
NM_031156.2
ncbi mol weight :
117,772 Da
ncbi pathways :
Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509)
uniprot summary :
IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; Cell surface; EC 3.4.24.56; Nuclear receptor co-regulator. Cellular Component: cell surface; cytoplasm; cytosol; extracellular region; extracellular space; membrane; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; plasma membrane. Molecular Function: ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; catalytic activity; glycoprotein binding; hydrolase activity; insulin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; nucleotide binding; peptidase activity; peptide binding; peptide hormone binding; protein homodimerization activity; receptor binding; ubiquitin binding; zinc ion binding. Biological Process: beta-amyloid metabolic process; cellular protein catabolic process; determination of adult life span; hormone catabolic process; metabolic process; negative regulation of proteolysis; peptide catabolic process; positive regulation of protein oligomerization; protein heterooligomerization; protein homooligomerization; protein homotetramerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process