catalog number :
MBS426628
products full name :
Fibroblast growth factor 21 Immunizing Peptide
products short name :
Fibroblast growth factor 21
products name syn :
Fibroblast growth factor 21; FGF21; Fibroblast growth factor 21; Fibroblast growth factor 21
other names :
fibroblast growth factor 21; Fibroblast growth factor 21; fibroblast growth factor 21; fibroblast growth factor 21
products gene name :
FGF21
other gene names :
FGF21; FGF21; FGF-21
uniprot entry name :
FGF21_HUMAN
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_061986.1
ncbi gb acc num :
NM_019113.3
ncbi mol weight :
22,300 Da
ncbi pathways :
Facilitative Na+-independent Glucose Transporters Pathway (1269924); Glucose Transport Pathway (1269921); Hexose Transport Pathway (1269920); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Melanoma Pathway (83114); Melanoma Pathway (526); Metabolism Pathway (1269956); Metabolism Of Carbohydrates Pathway (1269957); PI3K-Akt Signaling Pathway (692234)
ncbi summary :
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
uniprot summary :
FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: cell; extracellular region; extracellular space. Molecular Function: fibroblast growth factor receptor binding; growth factor activity; protein binding. Biological Process: cell-cell signaling; positive regulation of cell proliferation; positive regulation of glucose import; positive regulation of low-density lipoprotein receptor biosynthetic process; response to activity; response to nutrient levels; signal transduction; unfolded protein response