catalog number :
MBS426562
products full name :
Sak / STK18 / PLK4 Immunizing Peptide
products short name :
Sak / STK18 / PLK4
products name syn :
PLK4; Sak; polo-like kinase 4 (Drosophila); serine/threonine kinase 18; SAK; Snk Akin Kinase; polo-like kinase 4; protein-serine/threonine kinase; STK18; serine/threonine protein kinase SAK; Sak / STK18 / PLK4
other names :
serine/threonine-protein kinase PLK4 isoform 1; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase PLK4; polo like kinase 4; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase Sak
products gene name :
PLK4
products gene name syn :
Sak; STK18
other gene names :
PLK4; PLK4; SAK; STK18; MCCRP2; SAK; STK18; PLK-4
uniprot entry name :
PLK4_HUMAN
reactivity :
Human, Dog, Cow
sequence :
ATCIGEKIEDFKVGN
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_055079.3
ncbi gb acc num :
NM_014264.4
ncbi mol weight :
104,636 Da
ncbi pathways :
AURKA Activation By TPX2 Pathway (1383018); Anchoring Of The Basal Body To The Plasma Membrane Pathway (1268847); Assembly Of The Primary Cilium Pathway (1268846); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Centrosome Maturation Pathway (1269805); FoxO Signaling Pathway (921162); G2/M Transition Pathway (1269799); Loss Of Nlp From Mitotic Centrosomes Pathway (1269809); Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway (1269808)
ncbi summary :
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
uniprot summary :
PLK4: a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.21; Nucleolus; Protein kinase, Other; Other group; PLK family. Chromosomal Location of Human Ortholog: 4q28. Cellular Component: centriole; centrosome; cleavage furrow; cytosol; nucleolus; XY body. Molecular Function: ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity. Biological Process: centriole replication; G2/M transition of mitotic cell cycle; positive regulation of centriole replication; protein amino acid phosphorylation. Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2