protein

IA2 Immunizing Peptide

MBS426456

0.1 mg

190 USD

Peptide

IA2 Immunizing Peptide

IA2

IA-2; protein tyrosine phosphatase, receptor type, N; FLJ16131; IA-2/PTP; IA2; ICA512; R-PTP-N; islet antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N

receptor-type tyrosine-protein phosphatase-like N isoform 1; Receptor-type tyrosine-protein phosphatase-like N; receptor-type tyrosine-protein phosphatase-like N; protein tyrosine phosphatase, receptor type N; Islet cell antigen 512

PTPRN

IA2

PTPRN; PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; ICA3; ICA512; ICA 512

PTPRN_HUMAN

Human, Mouse, Rat

979

C-QGEGNIKKNRHPD

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

4506321

NP_002837.1

NM_002846.3

96,261 Da

Type I Diabetes Mellitus Pathway (83095); Type I Diabetes Mellitus Pathway (507)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor protein phosphatase, tyrosine. Chromosomal Location of Human Ortholog: 2q35-q36.1. Cellular Component: cell junction; cell soma; endosome; Golgi apparatus; integral to membrane; nerve terminal; perikaryon; plasma membrane; secretory granule; synapse; synaptic vesicle. Molecular Function: GTPase binding; protein binding; protein tyrosine phosphatase activity; spectrin binding. Biological Process: cytokine and chemokine mediated signaling pathway; insulin secretion; luteinization; protein amino acid dephosphorylation; response to cAMP; response to estrogen stimulus; response to insulin stimulus; response to reactive oxygen species

0.1 mg

190 USD