protein

IKAROS / IKZF1 Immunizing Peptide

MBS426326

0.1 mg

190 USD

Peptide

IKAROS / IKZF1 Immunizing Peptide

IKAROS / IKZF1

IKZF1; IKAROS family zinc finger 1 (Ikaros); Hs.54452; IK1; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1; CLL-associated antigen KW-6; Ikaros (zinc finger protein); zinc finger protein, subfamily 1A, 1 (Ikaros); lymphoid transcription factor LyF-1; IKAROS / IKZF1

DNA-binding protein Ikaros isoform 1; DNA-binding protein Ikaros; DNA-binding protein Ikaros; IKAROS family zinc finger 1; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1

IKZF1

IKAROS

IKZF1; IKZF1; IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452; IK1; IKAROS; LYF1; ZNFN1A1

IKZF1_HUMAN

Human, Dog, Cow

519

C-DTPYDSSASYEKEN

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

5174501

NP_006051.1

NM_006060.5

24,470 Da

Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993)

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

0.1 mg

190 USD