catalog number :
MBS426249
products full name :
ABCC1 Immunizing Peptide
products short name :
ABCC1
products name syn :
ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP; MRP1; ATP-binding cassette, sub-family C, member 1; LTC4 transporter; leukotriene C(4) transporter; multidrug resistance protein; multipl; ABCC1
other names :
multidrug resistance-associated protein 1; Multidrug resistance-associated protein 1; multidrug resistance-associated protein 1; ATP binding cassette subfamily C member 1; ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
products gene name :
ABCC1
other gene names :
ABCC1; ABCC1; MRP; ABCC; GS-X; MRP1; ABC29; MRP; MRP1; LTC4 transporter
uniprot entry name :
MRP1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence :
C-HQSDLKVDENQKAYY
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_004987.2
ncbi gb acc num :
NM_004996.3
ncbi mol weight :
172,640 Da
ncbi pathways :
ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (1269904); Arachidonic Acid Metabolism Pathway (1270087); Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway (1270152); Irinotecan Pathway (198905); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Vitamins And Cofactors Pathway (1270144); Metabolism Of Water-soluble Vitamins And Cofactors Pathway (1270145)
ncbi summary :
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
uniprot summary :
ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. Protein type: Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter. Chromosomal Location of Human Ortholog: 16p13.1. Cellular Component: basolateral plasma membrane; integral to plasma membrane; membrane; plasma membrane. Molecular Function: anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; cobalamin-transporting ATPase activity; transporter activity. Biological Process: cobalamin metabolic process; cobalamin transport; leukotriene metabolic process; response to drug; transmembrane transport; transport