protein

Wiskott-Aldrich Syndrome / WASP Immunizing Peptide

MBS426192

0.1 mg

190 USD

Peptide

Wiskott-Aldrich Syndrome / WASP Immunizing Peptide

Wiskott-Aldrich Syndrome / WASP

WAS; WASP; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); THC; IMD2; thrombocytopenia 1 (X-linked); Wiskott-Aldrich syndrome (eczema-thrombocytopenia) protein; THC1; Wiskott-Aldrich syndrome protein; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome / WASP

wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein; wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome

WAS

WASP

WAS; WAS; THC; IMD2; SCNX; THC1; WASP; WASPA; IMD2; WASp

WASP_HUMAN

Human, Mouse, Rat, Dog

502

C-SPADKKRSGKKKI

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

4507909

NP_000368.1

NM_000377.2

52,913 Da

Adaptive Immune System Pathway (1269171); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232)

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]

WASP: a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: Xp11.4-p11.21. Cellular Component: actin cytoskeleton; cytosol; intercellular junction; vesicle membrane. Molecular Function: actin binding; GTPase regulator activity; identical protein binding; phospholipase binding; protein binding; protein kinase binding; SH3 domain binding. Biological Process: actin filament polymerization; actin filament-based movement; actin polymerization and/or depolymerization; blood coagulation; defense response; endosome transport; epidermis development; immune response; protein complex assembly; regulation of catalytic activity; regulation of T cell antigen processing and presentation; T cell activation; T cell receptor signaling pathway. Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1

0.1 mg

190 USD