catalog number :
MBS426158
products full name :
TGFBI Immunizing Peptide
products short name :
TGFBI
products name syn :
TGFBI; transforming growth factor, beta-induced, 68kDa; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1; RGD-containing collagen-associated protein; kerato-epithelin
other names :
transforming growth factor-beta-induced protein ig-h3; Transforming growth factor-beta-induced protein ig-h3; transforming growth factor-beta-induced protein ig-h3; transforming growth factor beta induced; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
products gene name :
TGFBI
other gene names :
TGFBI; TGFBI; CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1; BIGH3; Beta ig-h3; RGD-CAP
uniprot entry name :
BGH3_HUMAN
reactivity :
Human, Mouse, Rat, Dog
sequence :
C-QLYTDRTEKLRPE
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_000349.1
ncbi gb acc num :
NM_000358.2
ncbi mol weight :
74,681 Da
ncbi pathways :
Amyloid Fiber Formation Pathway (1269169); Metabolism Of Proteins Pathway (1268677)
ncbi summary :
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
uniprot summary :
betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Protein type: Cell adhesion; Secreted; Secreted, signal peptide; Extracellular matrix. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; plasma membrane; proteinaceous extracellular matrix; trans-Golgi network. Molecular Function: collagen binding; extracellular matrix binding; integrin binding; protein binding. Biological Process: angiogenesis; cell adhesion; cell proliferation; cellular protein metabolic process; chondrocyte differentiation; extracellular matrix organization and biogenesis; negative regulation of cell adhesion; response to stimulus; visual perception. Disease: Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Groenouw Type I; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy, Lattice Type Iiia