protein

LIGHT / CD258 Immunizing Peptide

MBS426153

0.1 mg

190 USD

Blocking Peptide

LIGHT / CD258 Immunizing Peptide

[LIGHT / CD258]

[TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; CD258; HVEML; LIGHT; LTg; TR2; delta transmembrane LIGHT; herpesvirus entry mediator A; ligand for herpesvirus entry mediator; tumor necrosis factor ligand superfamily, member 14; tumor necro; LIGHT / CD258]

[tumor necrosis factor ligand superfamily member 14 isoform 1; Tumor necrosis factor ligand superfamily member 14; tumor necrosis factor ligand superfamily member 14; tumor necrosis factor superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand]

[TNFSF14]

[LIGHT; CD258]

[TNFSF14; TNFSF14; LTg; CD258; HVEML; LIGHT; HVEML; LIGHT; HVEM-L; Herpesvirus entry mediator ligand]

TNF14_HUMAN

C-HEVNPAAHLTGANS

100ug of lyophilized peptide, formulation 5pmol/ul in 5% (v/v) acetonitrile/H2O. Reconstitute pellet in distilled water where required. For Blocking studies, reconstitute pellet in 200ul distilled water to obtain a 0.5mg/ml peptide solution.

Shipped at ambient temperature, store at -20°C.

Use: This peptide was used in the production MBS426153 - Goat Anti-LIGHT / CD258 Antibody. It is currently untested in blocking applications.

25952144

NP_003798.2

NM_003807.4

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Immune System Pathway (1269170); NF-kappa B Signaling Pathway (634527); NF-kappa B Signaling Pathway (634652); TNF Receptor Superfamily (TNFSF) Members Mediating Non-canonical NF-kB Pathway (1269330); TNFR2 Non-canonical NF-kB Pathway (1269329)

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TNFSF14: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cytokine; Inhibitor. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: cytoplasm; extracellular space; integral to membrane; plasma membrane. Molecular Function: caspase inhibitor activity; cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding. Biological Process: apoptosis; immune response; negative regulation of caspase activity; positive regulation of myoblast differentiation; release of cytoplasmic sequestered NF-kappaB; signal transduction; T cell activation; T cell costimulation; T cell homeostasis; T cell proliferation; tumor necrosis factor-mediated signaling pathway

0.1 mg

190 USD