protein

Collagen, type VII Immunizing Peptide

MBS426106

0.1 mg

190 USD

Peptide

Collagen, type VII Immunizing Peptide

Collagen, type VII

Collagen, type VII; collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive); COL7A1; HGNC: 2214; EBD1; EBDCT; EBR1; LC collagen; alpha 1 type VII collagen; collagen VII; alpha-1 polypeptide; long chain collagen; collagen, ty; Collagen, type VII; Collagen, type VII

collagen alpha-1(VII) chain; Collagen alpha-1(VII) chain; collagen alpha-1(VII) chain; collagen type VII alpha 1; Long-chain collagen; LC collagen

COL7A1

COL7A1; COL7A1; EBD1; EBR1; EBDCT; NDNC8; LC collagen

CO7A1_HUMAN

Human, Mouse, Rat, Dog, Pig

2944

C-TVQYSDDPRTEF

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

4502961

NP_000085.1

NM_000094.3

292,267 Da

Anchoring Fibril Formation Pathway (1270248); Asparagine N-linked Glycosylation Pathway (1268714); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); COPII (Coat Protein 2) Mediated Vesicle Transport Pathway (1268727); Cargo Concentration In The ER Pathway (1309087); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Formation Pathway (1270245); ER To Golgi Anterograde Transport Pathway (1268726); Extracellular Matrix Organization Pathway (1270244); Membrane Trafficking Pathway (1269877)

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]

COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Extracellular matrix; Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 3p21.1. Cellular Component: basement membrane; collagen type VII; endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular matrix; extracellular region; extracellular space; Golgi membrane. Molecular Function: identical protein binding; protein binding; serine-type endopeptidase inhibitor activity. Biological Process: cell adhesion; collagen catabolic process; COPII coating of Golgi vesicle; epidermis development; ER to Golgi vesicle-mediated transport; extracellular matrix organization and biogenesis. Disease: Epidermolysis Bullosa Dystrophica, Autosomal Dominant; Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Epidermolysis Bullosa Dystrophica, Pretibial; Epidermolysis Bullosa Pruriginosa; Epidermolysis Bullosa With Congenital Localized Absence Of Skin And Deformity Of Nails; Nail Disorder, Nonsyndromic Congenital, 8; Transient Bullous Dermolysis Of The Newborn

0.1 mg

190 USD