catalog number :
MBS425936
products full name :
ABCA2 Immunizing Peptide
products short name :
ABCA2
products name syn :
ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2; ABC2; MGC129761; ATP-binding cassette, sub-family A, member 2; OTTHUMP00000064733
other names :
ATP-binding cassette sub-family A member 2 isoform a; ATP-binding cassette sub-family A member 2; ATP-binding cassette sub-family A member 2; ATP binding cassette subfamily A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2
products gene name :
ABCA2
other gene names :
ABCA2; ABCA2; ABC2; ABC2; KIAA1062; ATP-binding cassette 2
uniprot entry name :
ABCA2_HUMAN
reactivity :
Human, Mouse, Rat
sequence :
C-KKQSDNLEQQETEP
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_001597.2
ncbi gb acc num :
NM_001606.4
ncbi mol weight :
269,988 Da
ncbi pathways :
ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC Transporters In Lipid Homeostasis Pathway (1269905); ABC-family Proteins Mediated Transport Pathway (1269904); Lysosome Pathway (99052); Lysosome Pathway (96865); Transmembrane Transport Of Small Molecules Pathway (1269903)
ncbi summary :
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ABC family. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: ATP-binding cassette (ABC) transporter complex; cytoplasmic membrane-bound vesicle; endosome; endosome membrane; integral to membrane; lysosomal membrane; lysosome; membrane; microtubule organizing center. Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding. Biological Process: cholesterol efflux; cholesterol homeostasis; lipid metabolic process; phospholipid efflux; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus; transmembrane transport; transport