protein

CCKBR Immunizing Peptide

MBS425779

0.1 mg

190 USD

Blocking Peptide

CCKBR Immunizing Peptide

[CCKBR]

[CCKBR; cholecystokinin B receptor; HGNC: 1571; CCK-B; GASR; CCK2 receptor; cholecystokinin-B receptor/gastrin receptor; gastrin receptor; gastrin cholecystokinin brain receptor; CCK2R]

[gastrin/cholecystokinin type B receptor isoform 1; Gastrin/cholecystokinin type B receptor; gastrin/cholecystokinin type B receptor; cholecystokinin B receptor; Cholecystokinin-2 receptor; CCK2-R]

[CCKBR]

[CCKBR; CCKBR; GASR; CCK-B; CCK2R; CCKRB; CCK-B receptor; CCK-BR; CCK2-R]

GASR_HUMAN

447

C-FDGDSDSDSQSRVRNQ

100ug of lyophilized peptide formulation 5pmol/uL in 5% (v/v) acetonitrile/H2O. Reconstitute pellet in distilled water where required. For blocking studies, reconstitute pellet in 200ul distilled water to obtain a 0.5mg/ml peptide solution.

Shipped at ambient temperature, store at -20 degree C

The peptide was used in the production of MBS421039- Goat Anti-CCKBR Antibody. It is currently untested in blocking applications.

28875799

NP_795344.1

NM_176875.3

41,504 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383)

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]

CCKBR: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 11p15.4. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: 1-phosphatidylinositol-3-kinase regulator activity; cholecystokinin receptor activity; gastrin receptor activity; phosphoinositide phospholipase C activity; protein binding; type B gastrin/cholecystokinin receptor binding. Biological Process: cell proliferation; cell surface receptor linked signal transduction; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); gastric acid secretion; gland development; gut development; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase activity; sensory perception

0.1 mg

190 USD