protein

ACO1 / Aconitase 1 Immunizing Peptide

MBS425714

0.1 mg

190 USD

Peptide

ACO1 / Aconitase 1 Immunizing Peptide

ACO1 / Aconitase 1

ACO1; aconitase 1, soluble; ACONS; IREB1; IREBP; IREBP1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; aconitase 1; aconitate hydratase; citrate hydro-lyase; ferritin repressor protein; iron regulatory protein 1; iron-responsive elemen; Aconitase 1; ACO1 / Aconitase 1

cytoplasmic aconitate hydratase; Cytoplasmic aconitate hydratase; cytoplasmic aconitate hydratase; aconitase 1; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1

ACO1

ACO1; ACO1; IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1; IREB1; Aconitase; IRP1; IRE-BP 1

ACOC_HUMAN

Human, Mouse, Rat, Cow

889

C-QVDFNRRADSLQKNQ

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

8659555

NP_002188.1

NM_002197.2

98,399 Da

2-Oxocarboxylic Acid Metabolism Pathway (714485); 2-Oxocarboxylic Acid Metabolism Pathway (717400); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Citrate Cycle (TCA Cycle) Pathway (82927); Citrate Cycle (TCA Cycle) Pathway (288); Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway (855811); Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway (468202)

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

IREB1: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Belongs to the aconitase/IPM isomerase family. Protein type: EC 4.2.1.3; Lyase; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle; Endoplasmic reticulum; Translation; RNA-binding. Chromosomal Location of Human Ortholog: 9p21.1. Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; mitochondrion. Molecular Function: 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; iron-responsive element binding; metal ion binding; protein binding; RNA binding. Biological Process: cellular iron ion homeostasis; citrate metabolic process; intestinal absorption; post-embryonic development; regulation of translation; response to iron(II) ion; tricarboxylic acid cycle

0.1 mg

190 USD