protein

ATG5 Immunizing Peptide

MBS425598

0.1 mg

190 USD

Peptide

ATG5 Immunizing Peptide

ATG5

ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae); APG5; APG5L; ASP; hAPG5; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like; ATG5 autophagy related 5-like; OTTHUMP00000040507; apoptosis specific protein

autophagy protein 5 isoform a; Autophagy protein 5; autophagy protein 5; autophagy related 5; APG5-like; Apoptosis-specific protein

ATG5

ATG5; ATG5; ASP; APG5; APG5L; hAPG5; APG5-LIKE; APG5L; ASP

ATG5_HUMAN

Human, Mouse, Cow, Horse

275

C-SQVINEMQKKDHKQ

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

4757798

NP_004840.1

NM_004849.3

22,931 Da

Cellular Responses To Stress Pathway (1270414); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Longevity Regulating Pathway (1319989); Longevity Regulating Pathway - Multiple Species (1340713); Longevity Regulating Pathway - Multiple Species (1340651); Macroautophagy Pathway (1270432); Mitophagy Pathway (1309218); Negative Regulators Of RIG-I/MDA5 Signaling Pathway (1269264); Pink/Parkin Mediated Mitophagy Pathway (1309219)

The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

ATG5: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin conjugating system; Autophagy; Apoptosis. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: autophagic vacuole; axoneme; cytoplasm; cytosol; membrane; phagocytic vesicle membrane; pre-autophagosomal structure membrane. Molecular Function: APG8 conjugating enzyme activity; protein binding. Biological Process: antigen processing and presentation of endogenous antigen; apoptosis; autophagic vacuole formation; autophagy; blood vessel remodeling; C-terminal protein lipidation; cellular homeostasis; cellular response to nitrogen starvation; heart contraction; innate immune response; macroautophagy; mitochondrion degradation; negative regulation of apoptosis; negative regulation of protein ubiquitination; negative thymic T cell selection; otolith development; post-translational protein modification; regulation of cytokine secretion during immune response; regulation of release of sequestered calcium ion into cytosol; response to drug; response to fungus; vasodilation; ventricular cardiac muscle cell development

0.1 mg

190 USD