catalog number :
MBS425561
products full name :
OX1R and OX2R Immunizing Peptide
products short name :
OX1R and OX2R
products name syn :
OX1R; OX2R; HCRTR1; hypocretin (orexin) receptor 1; hypocretin receptor 1; hypocretin receptor-1; orexin receptor 1; orexin receptor-1; HCRTR2; hypocretin (orexin) receptor 2; hypocretin receptor 2; hypocretin receptor-2; orexin receptor 2; orexin recepto; OX1R and OX2R
other names :
orexin receptor type 1; Orexin receptor type 1; orexin receptor type 1; hypocretin receptor 1; Hypocretin receptor type 1
products gene name :
HCRTR1
products gene name syn :
OX1R; OX2R
other gene names :
HCRTR1; HCRTR1; OX1R; Ox-1-R; Ox1-R; Ox1R
uniprot entry name :
OX1R_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence :
C-YNFLSGKFREQFK
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_001516.2
ncbi gb acc num :
NM_001525.2
ncbi mol weight :
47,536 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway (1269550); Peptide Ligand-binding Receptors Pathway (1269546)
ncbi summary :
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
uniprot summary :
HCRTR1: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR. Chromosomal Location of Human Ortholog: 1p33. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; neuropeptide receptor activity; orexin receptor activity; peptide binding; peptide hormone binding. Biological Process: cellular response to hormone stimulus; feeding behavior; neuropeptide signaling pathway; regulation of circadian sleep/wake cycle, sleep; synaptic transmission