protein

ABCD3 Immunizing Peptide

MBS425530

0.1 mg

190 USD

Peptide

ABCD3 Immunizing Peptide

ABCD3

ABCD3; ATP-binding cassette, sub-family D (ALD), member 3; ABC43; PMP70; PXMP1; ATP-binding cassette, sub-family D, member 3; Peroxisomal membrane protein-1 (70kD); dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); peroxisoma; ABCD3

ATP-binding cassette sub-family D member 3 isoform a; ATP-binding cassette sub-family D member 3; ATP-binding cassette sub-family D member 3; ATP binding cassette subfamily D member 3; 70 kDa peroxisomal membrane protein; PMP70

ABCD3

ABCD3; ABCD3; ZWS2; ABC43; CBAS5; PMP70; PXMP1; PMP70; PXMP1; PMP70

ABCD3_HUMAN

Human, Mouse, Rat

659

C-PDGREDQKRKGISD

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

4506341

NP_002849.1

NM_002858.3

27,121 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC Transporters In Lipid Homeostasis Pathway (1269905); ABC-family Proteins Mediated Transport Pathway (1269904); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Peroxisome Pathway (131226); Peroxisome Pathway (131126); Transmembrane Transport Of Small Molecules Pathway (1269903)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes. Protein type: Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass; Mitochondrial; Transporter. Chromosomal Location of Human Ortholog: 1p21.3. Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; membrane; mitochondrial inner membrane; peroxisomal matrix; peroxisomal membrane; peroxisome. Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity; protein self-association. Biological Process: fatty acid beta-oxidation; fatty acid biosynthetic process; peroxisomal long-chain fatty acid import; peroxisome organization and biogenesis; response to drug; response to organic cyclic substance; transmembrane transport; very-long-chain fatty acid catabolic process. Disease: Bile Acid Synthesis Defect, Congenital, 5

0.1 mg

190 USD